Keep track of Closely (one)phenobarbital will minimize the extent or effect of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the minimize in fentanyl plasma concentrations, not enough efficacy or, maybe, progress o